This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
5-Amino-1MQ
Nicotinamide N-methyltransferase Inhibitor
/WHAT_IT_IS
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide to 1-methylnicotinamide, thereby modulating NAD⁺ metabolism and influencing energy expenditure and adiposity.
/USAGE
Used in research to study NNMT activity, NAD⁺ salvage pathways, obesity, type 2 diabetes, and metabolic regulation.
/MECHANISM_OF_ACTION
Binds to the active site of NNMT, preventing methylation of nicotinamide, which leads to increased intracellular NAD⁺ levels, enhanced mitochondrial function, and reduced lipogenesis.
Reported Benefits
- +Increased NAD⁺ levels
- +Enhanced mitochondrial function
- +Reduced adiposity in diet-induced obesity models
- +Improved glucose tolerance
Reported Side Effects
- −Not well characterized in humans
- −Potential off-target effects at high doses
/RESEARCH_NOTES
In mouse studies, 5-Amino-1MQ reverses diet-induced obesity without affecting food intake and shows high selectivity over other methyltransferases. Human data are limited.
/REFERENCE
https://pubmed.ncbi.nlm.nih.gov/35013352/Browse all 89 in the app.
MyTRT's in-app library has the same 89 peptide entries plus dosing notes, stack builders, and the ability to log them alongside your TRT protocol.