This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
ACE-031
Soluble Activin Type IIB Receptor–Fc Fusion (Myostatin/Activin Ligand Trap)
/WHAT_IT_IS
ACE-031 (ActRIIB-Fc Ligand Trap) is a recombinant fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) linked to an IgG1 Fc fragment. It serves as a decoy receptor that binds myostatin (GDF8) and related ligands (e.g., activins), thereby reducing SMAD2/3 signaling to promote muscle and bone anabolism in research settings.
/USAGE
Used to study muscle-wasting disorders, sarcopenia/cachexia models, bone mass regulation, and downstream metabolic/functional outcomes (lean mass, strength, BMD).
/MECHANISM_OF_ACTION
Ligand trap that sequesters myostatin and select activins from ActRIIA/B receptors, attenuating TGF-β/SMAD2/3 signaling; results include increased muscle protein synthesis/hypertrophy and bone accrual.
Reported Benefits
- +Increases lean body mass and muscle volume in human and animal studies
- +May improve functional measures (e.g., 6-minute walk trends in DMD studies)
- +Associated increases in bone mineral density in some models
Reported Side Effects
- −Epistaxis (nosebleeds) and telangiectasias reported in clinical studies
- −Injection-site reactions (pain, pruritus, hematoma)
- −Potential vascular effects linked to broader ligand binding (e.g., BMP9/10 cross-reactivity in class)
/STACKED_WITH
/RESEARCH_NOTES
Clinical development in DMD was halted/terminated after non-muscle AEs (epistaxis, telangiectasias) despite PD signals for lean mass/BMD; contemporary designs aim to narrow ligand specificity to mitigate vascular findings. Not approved for therapeutic use.
/REFERENCE
https://pubmed.ncbi.nlm.nih.gov/23169607/Browse all 89 in the app.
MyTRT's in-app library has the same 89 peptide entries plus dosing notes, stack builders, and the ability to log them alongside your TRT protocol.