This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
ARA-290
Non-erythropoietic EPO-Derived Peptide
/WHAT_IT_IS
ARA-290 (cibinetide) is an 11–amino acid peptide engineered from erythropoietin’s helix-B that selectively activates the EPOR–CD131 ‘innate repair receptor’ to promote tissue protection, anti-inflammatory signaling, and small-fiber nerve repair without stimulating erythropoiesis.
/USAGE
Studied in small fiber neuropathy (e.g., sarcoidosis-associated and type 2 diabetes), ocular/ischemic injury models, and inflammatory conditions to evaluate symptom relief, nerve fiber regeneration, and improved metabolic/quality-of-life outcomes.
/MECHANISM_OF_ACTION
Binds the EPOR–CD131 heteroreceptor (innate repair receptor), triggering JAK2/STAT and PI3K/Akt pathways while suppressing NF-κB–mediated inflammation; restores tissue homeostasis and supports small-fiber nerve regrowth.
Reported Benefits
- +Reduces neuropathic pain and autonomic symptoms in SFN studies
- +Improves quality-of-life measures
- +Increases corneal small-fiber nerve density in clinical imaging
- +Anti-inflammatory, cytoprotective effects without erythropoiesis
- +Metabolic improvements noted in type 2 diabetes cohorts
Reported Side Effects
- −Generally well tolerated in trials
- −Mild injection-site reactions
- −No meaningful changes in hematocrit/hemoglobin (non-erythropoietic)
/STACKED_WITH
/RESEARCH_NOTES
Selective IRR activation aims to reprogram inflammatory microenvironments toward repair. Clinical studies in sarcoidosis-associated and diabetic SFN report symptom improvement and corneal nerve fiber regrowth, with a favorable safety profile despite a very short plasma half-life.
/REFERENCE
https://pubmed.ncbi.nlm.nih.gov/25387363/Browse all 89 in the app.
MyTRT's in-app library has the same 89 peptide entries plus dosing notes, stack builders, and the ability to log them alongside your TRT protocol.