This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
FOX04-DRI (10 mg)
Senolytic Peptide
/WHAT_IT_IS
FOX04‑DRI (Retro‑Inverso) is a synthetic peptide designed to interfere with the FOXO4/p53 interaction, enabling selective induction of apoptosis in senescent cells to improve tissue function and biological age.
/USAGE
Used in research to remove senescent cells and study aging, tissue regeneration, insulin signaling, and cell cycle control.
/MECHANISM_OF_ACTION
Acts as a cell‑penetrating peptide that disrupts FOXO4 binding to p53, freeing p53 to induce apoptosis in senescent cells.
Reported Benefits
- +Selective clearance of senescent cells
- +Improved organ and tissue function
- +Reduced aging‑related inflammatory signaling
- +Enhanced insulin sensitivity and metabolic outcomes
Reported Side Effects
- −Limited human safety data
- −Potential off‑target effects in non‑senescent cells
/RESEARCH_NOTES
Demonstrated senolytic effects in preclinical studies by disrupting FOXO4-p53 binding, leading to selective apoptosis in senescent cells. Shows promise in age-related disease models and fibrosis. For research use only.
/REFERENCE
https://pubmed.ncbi.nlm.nih.gov/28340339/Browse all 89 in the app.
MyTRT's in-app library has the same 89 peptide entries plus dosing notes, stack builders, and the ability to log them alongside your TRT protocol.