This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
MK-677 (Ibutamoren)
Growth Hormone Secretagogue / Ghrelin Mimetic
/WHAT_IT_IS
MK-677, also known as Ibutamoren, is an orally active growth hormone secretagogue that mimics the action of the hormone ghrelin and stimulates growth hormone (GH) release.
/USAGE
Studied for its effects on increasing growth hormone and IGF-1 levels, supporting muscle growth, fat loss, recovery, and anti-aging. Common in bodybuilding and longevity research.
/MECHANISM_OF_ACTION
Binds to ghrelin receptors in the brain, stimulating the pituitary gland to secrete more growth hormone and subsequently increase IGF-1 levels.
Reported Benefits
- +Increases growth hormone and IGF-1 levels
- +Promotes muscle growth and recovery
- +Improves sleep quality (REM and deep sleep)
- +Supports fat loss
- +May improve bone density
Reported Side Effects
- −Increased appetite
- −Water retention and mild edema
- −Lethargy (especially during initial use)
- −Possible insulin resistance or increased blood sugar
- −Mild numbness or tingling in extremities
/STACKED_WITH
/RESEARCH_NOTES
Does not suppress natural testosterone or HPTA; often used long-term in research settings. Increases hunger, which can be beneficial for bulking.
/REFERENCE
https://pubmed.ncbi.nlm.nih.gov/8626843//RELATED
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