This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
Raloxifene
Selective Estrogen Receptor Modulator (SERM)
/WHAT_IT_IS
Raloxifene is a benzothiophene SERM that acts as an estrogen agonist in bone and liver but an antagonist in breast and uterine tissue.
/USAGE
Clinically used to prevent and treat postmenopausal osteoporosis and reduce the risk of estrogen receptor–positive breast cancer; off-label in men for gynecomastia and HPTA support.
/MECHANISM_OF_ACTION
Binds estrogen receptors with tissue specificity: agonist effects in bone (improving BMD); antagonist effects in breast/uterus (reducing cancer risk) :contentReference[oaicite:1]{index=1}.
Reported Benefits
- +Prevents vertebral and non‑vertebral fractures; increases bone mineral density :contentReference[oaicite:2]{index=2}
- +Reduces risk of invasive ER+ breast cancer by ~38% :contentReference[oaicite:3]{index=3}
- +Improves lipid profile by lowering LDL cholesterol and C‑reactive protein :contentReference[oaicite:4]{index=4}
- +Disinhibits HPTA in men, increasing total testosterone (free often unchanged) :contentReference[oaicite:5]{index=5}
Reported Side Effects
- −Hot flashes, leg cramps, swelling, arthralgia/joint pain :contentReference[oaicite:6]{index=6}
- −Increased risk of venous thromboembolism (DVT/PE) and stroke :contentReference[oaicite:7]{index=7}
- −May cause flu‑like symptoms and vaginal dryness
- −No increased risk of endometrial cancer :contentReference[oaicite:8]{index=8}
/STACKED_WITH
/RESEARCH_NOTES
Well-established long-term safety and efficacy in reducing fractures; enterohepatic recycling contributes to long half‑life; no CYP450 metabolism :contentReference[oaicite:10]{index=10}.
/REFERENCE
https://www.ncbi.nlm.nih.gov/books/NBK544233/Browse all 89 in the app.
MyTRT's in-app library has the same 89 peptide entries plus dosing notes, stack builders, and the ability to log them alongside your TRT protocol.