/DISCLAIMER · RESEARCH_COMPOUND

This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.

/TESOFENSINE_POWDER
Peptide

Tesofensine Powder

Triple Monoamine Reuptake Inhibitor

/HALF_LIFE
Approximately 8 days
/DELIVERY
Oral (capsule or powder form)

/WHAT_IT_IS

Tesofensine is a serotonin–noradrenaline–dopamine reuptake inhibitor (SNDRI) that was originally developed for neurodegenerative diseases and later studied for its potent weight loss effects.

/USAGE

Used in research focused on appetite suppression and weight loss. May enhance energy expenditure and reduce food cravings.

/MECHANISM_OF_ACTION

Blocks the reuptake of serotonin, norepinephrine, and dopamine, increasing their levels and thereby reducing appetite and promoting satiety.

Reported Benefits

  • +Appetite suppression
  • +Potential weight loss
  • +Enhanced mood and energy

Reported Side Effects

  • Dry mouth
  • Increased heart rate
  • Insomnia
  • Elevated blood pressure

/STACKED_WITH

CagrilintideGLP-1 analogsLow-dose stimulants (under research)

/RESEARCH_NOTES

Has shown significant weight loss potential in clinical trials. Requires careful dosing due to strong CNS stimulation.

/REFERENCE

https://pubmed.ncbi.nlm.nih.gov/18950853/

/RELATED

/TRACK_THIS

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Last reviewed: 2026-06-04 · Reference only. Not medical advice. Consult a qualified physician.