This page is reference information only. Most compounds described here are research chemicals, not FDA-approved medications. MyTRT does not sell, recommend, or endorse the use of these substances. Always consult a qualified physician.
VIP
Neuropeptide / Immunomodulatory Peptide
/WHAT_IT_IS
VIP (Vasoactive Intestinal Peptide) is a 28–amino acid neuropeptide widely distributed in the CNS, lungs, and gut. It exerts potent vasodilatory, bronchodilatory, and immunomodulatory effects and is studied for roles in airway tone, mucosal protection, and neuroimmune signaling.
/USAGE
Research on airway diseases (bronchodilation, mucus regulation), gastrointestinal motility/secretions and barrier function, neuroprotection, and immune modulation (anti-inflammatory, Th2/Treg bias).
/MECHANISM_OF_ACTION
Binds VPAC1/VPAC2 (class B GPCRs) to activate Gs→adenylate cyclase→cAMP/PKA signaling, relaxing smooth muscle, enhancing epithelial secretion, and modulating cytokines; rapidly degraded by peptidases (e.g., DPP-IV, neutral endopeptidase).
Reported Benefits
- +Bronchodilation and airway smooth-muscle relaxation
- +Vasodilation and improved microcirculatory flow
- +Reduced pro-inflammatory cytokine signaling
- +Support for epithelial barrier integrity and mucus regulation
- +Neuroprotective/neuromodulatory effects in CNS models
Reported Side Effects
- −Flushing and warmth
- −Headache or lightheadedness
- −Transient hypotension or tachycardia (dose-dependent)
- −Nasal/throat irritation with intranasal or inhaled use
- −GI cramping or diarrhea in sensitive subjects
/STACKED_WITH
/RESEARCH_NOTES
Owing to rapid enzymatic degradation, protocols often explore stabilized analogs (e.g., aviptadil) or delivery vehicles to extend residence time. Outcomes typically track spirometry/airway responsiveness, hemodynamics, cytokine panels, and epithelial barrier metrics.
/REFERENCE
https://en.wikipedia.org/wiki/Vasoactive_intestinal_peptide/RELATED
Browse all 89 in the app.
MyTRT's in-app library has the same 89 peptide entries plus dosing notes, stack builders, and the ability to log them alongside your TRT protocol.